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IFN-γ-adsorbed DMSA-coated magnetite nanoparticles can be used as an efficient in vivo drug delivery system for
tumor immunotherapy. Magnetic nanoparticles, with adsorbed interferon-γ, were targeted to the tumor site by application
of an external magnetic field. A relevant therapeutic dosage of interferon in the tumor was detected and led to a notable
reduction in tumor size. In general, only 10% of the total injected nanoparticles after multiple exposures were found in
tissues by AC susceptibility measurements of the corresponding resected tissues. Magnetic nanoparticle biodistribution
is affected by the application of an external magnetic field.
L. Gutiérrez,R. Mejías,D. F. Barber,S. Veintemillas-Verdaguer,C. J. Serna,F. J. Lázaro, andM. P. Morales
"Fighting cancer with magnetic nanoparticles and immunotherapy", Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320X (2 February 2012); https://doi.org/10.1117/12.905890
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L. Gutiérrez, R. Mejías, D. F. Barber, S. Veintemillas-Verdaguer, C. J. Serna, F. J. Lázaro, M. P. Morales, "Fighting cancer with magnetic nanoparticles and immunotherapy," Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320X (2 February 2012); https://doi.org/10.1117/12.905890