Simulating the demyelination of a nerve fiber by action potential encoded second harmonic generation

Hong-Qin Yang; Zhihui Luo; Xinguang Chen; Yimei Huang; Shusen Xie

doi:10.1117/12.999768

11 December 2012 Simulating the demyelination of a nerve fiber by action potential encoded second harmonic generation

Hong-Qin Yang, Zhihui Luo, Xinguang Chen, Yimei Huang, Shusen Xie

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85530Z (2012) https://doi.org/10.1117/12.999768
Event: Photonics Asia, 2012, Beijing, China

Abstract

Demyelination of a nerve fiber was simulated by action potential encoded second harmonic generation (SHG). The dynamics of action potential propagation along a nerve fiber with a multi-internode demyelination happening to successive internodes or intermittent internodes was studied. The results showed the attenuation and delay of action potential could obviously occur, and the refractory period increased when a nerve was demyelinated. In addition, under the same thickness and number of the demyelination, the peak of SHG signals attenuated much more along successive injured internodes than along intermittent injured internodes. It indicated that action potential encoded SHG could be a useful tool for detecting nerve demyelination.

Citation Download Citation

Hong-Qin Yang, Zhihui Luo, Xinguang Chen, Yimei Huang, and Shusen Xie "Simulating the demyelination of a nerve fiber by action potential encoded second harmonic generation", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85530Z (11 December 2012); https://doi.org/10.1117/12.999768

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available