Influence of tissue treatment onto the Raman spectra obtained from prostate histopathological slides for diagnostic purposes

Jason Wander; Sinisa Vukelic

doi:10.1117/12.2003406

8 March 2013 Influence of tissue treatment onto the Raman spectra obtained from prostate histopathological slides for diagnostic purposes

Jason Wander, Sinisa Vukelic

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85651F (2013) https://doi.org/10.1117/12.2003406
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In recent years, Raman spectroscopy has emerged as a potentially viable tool for automated cancer diagnostics. However, due to the complexity of the signal obtained from a tissue, most of the studies have been confined to statistical analysis of the spectra with principal component analysis being most often reported as the analysis of choice. These types of analyses are sensitive to modification of the Raman spectra due to tissue processing. The study presented here addresses the modifications of the Raman spectra obtained from prostate tissue histopathological slides due to the tissue treatment and its influence on the automated cancer diagnostics via Raman spectroscopy.

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Jason Wander and Sinisa Vukelic "Influence of tissue treatment onto the Raman spectra obtained from prostate histopathological slides for diagnostic purposes", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651F (8 March 2013); https://doi.org/10.1117/12.2003406

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