A novel sensor for high throughput preclinical radiotracer imaging

Haris Kudrolli; Harish B. Bhandari; Katherine L. Byrne; Simon R. Cherry; Gregory S. Mitchell; Hamid Sabet; Vivek Nagarkar

doi:10.1117/12.2008165

6 March 2013 A novel sensor for high throughput preclinical radiotracer imaging

Haris Kudrolli, Harish B. Bhandari, Katherine L. Byrne, Simon R. Cherry, Gregory S. Mitchell, Hamid Sabet, Vivek Nagarkar

Author Affiliations +

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 866809 (2013) https://doi.org/10.1117/12.2008165
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Preclinical imaging is a cornerstone of translational research, as all therapeutic drugs need to be tested for efficacy and toxicity on animals prior to human trials. Optical imaging techniques, such as bioluminescence and multispectral fluorescence imaging, currently dominate preclinical functional imaging despite their depth dependent limitations on quantitation and sensitivity. Translating drugs developed with these techniques to clinical models can therefore be difficult. Hence, clinically relevant nuclear imaging techniques, such as SPECT and PET, are therefore becoming increasingly used in preclinical imaging. Dedicated preclinical SPECT and PET systems are now available, but for many preclinical research groups this requires a significant investment in new equipment.

Citation Download Citation

Haris Kudrolli, Harish B. Bhandari, Katherine L. Byrne, Simon R. Cherry, Gregory S. Mitchell, Hamid Sabet, and Vivek Nagarkar "A novel sensor for high throughput preclinical radiotracer imaging", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 866809 (6 March 2013); https://doi.org/10.1117/12.2008165

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