On-chip optofluidic grating spectrograph for biomedical applications

Zhenyu Li

doi:10.1117/12.2024601

28 September 2013 On-chip optofluidic grating spectrograph for biomedical applications

Zhenyu Li

Proceedings Volume 8845, Ultrafast Imaging and Spectroscopy; 88450P (2013) https://doi.org/10.1117/12.2024601
Event: SPIE Optical Engineering + Applications, 2013, San Diego, California, United States

Abstract

This paper presents a liquid metal based on-chip optofluidic grating spectrograph integrated with polydimethylsiloxane (PDMS) microfluidics for biomedical applications such as handheld fluorescence-actuated cell sorting, fluorescence immunosensing and Raman spectroscopy. We designed a Czerny-Turner spectrograph with 1.4nm spectral resolution, 300nm FSR and a footprint of 1cm by 2cm. The spectrograph structure was fabricated in PDMS using conventional replica molding soft lithography, and then filled with room temperature liquid metal, Gallium-Indium-Tin Alloy. The material and fabrication method is fully compatible with PDMS microfluidics, which allowed us to integrate a sheath flow based microfluidic cell focusing system with the spectrograph on the same substrate. This integration represents an important step towards a handheld flow cytometer. In addition, as a new class of on-chip optofluidic components, liquid metallic optical elements such as mirrors, gratings and pinholes will likely find other applications for building miniaturized optofluidic systems.

Citation Download Citation

Zhenyu Li "On-chip optofluidic grating spectrograph for biomedical applications", Proc. SPIE 8845, Ultrafast Imaging and Spectroscopy, 88450P (28 September 2013); https://doi.org/10.1117/12.2024601

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