Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC

I. Shishkovsky; S. Volchkov

doi:10.1117/12.2035550

28 November 2013 Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC

I. Shishkovsky, S. Volchkov

Author Affiliations +

Proceedings Volume 9065, Fundamentals of Laser-Assisted Micro- and Nanotechnologies 2013; 906515 (2013) https://doi.org/10.1117/12.2035550
Event: Fundamentals of Laser Assisted Micro- and Nanotechnologies 2013, 2013, St. Petersburg, Russian Federation

Abstract

The objective of the investigation was to test the biocompatibility of 3D porous biopolymer matrices (tissue-cellular scaffolds), made of biocompatible and bioresorbable polymers (polycarbonate, polyetheretherketone /PEEK/, polycaprolactone), including the materials with biocompatible oxide ceramics additive (TiO₂, Al₂O₃, ZrO₂ and hydroxyapatite) of micron and nano sizes, for tissue-engineering purposes. The porous samples were prepared via a layer-by-layer SLS method. The surface microstructures and their roughness were analyzed by the optical microscopy equipped with the cell analysis software. The cellular morphology, proliferative activity and adhesion of the polymeric and ceramopolymeric matrices were the subjects for comparison. The study showed that all the tested materials posessed biocompatible properties. The experimentally estimated cell duplication speed per day turned out to be maximal for polycarbonate (0.279 duplications per day) and for PEEK + Al₂O₃ = 3:1 group (0.30 dupl/day) against 0.387 dupl/day for the reference sample and 0.270 dupl/day for the group of cells placed close to the pure titanium samples.

Citation Download Citation

I. Shishkovsky and S. Volchkov "Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC ", Proc. SPIE 9065, Fundamentals of Laser-Assisted Micro- and Nanotechnologies 2013, 906515 (28 November 2013); https://doi.org/10.1117/12.2035550

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