Review Of Fluorescence Diagnosis Using Porphyrins

A E Profio

doi:10.1117/12.945332

15 June 1988 Review Of Fluorescence Diagnosis Using Porphyrins

A E Profio

Proceedings Volume 0907, Laser Surgery: Characterization and Therapeutics; (1988) https://doi.org/10.1117/12.945332
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States

Abstract

Tumors can be detected by their increased fluorescence compared to surrounding tissue, several hours after injection of a fluorescent, tumor-localizing compound such as dihematoporphyrin ether. The fluorescence is observed by either a nonimaging photodetector, with appropriate filters, or by an imaging optical system (usually employing an image intensifier because the fluorescence is weak). Excitation is best carried out with a laser, but a filtered arc lamp may be suitable. Instruments differ in the methods of excitation, detection, reduction of background from native fluorescence of tissues, and provision for a whitelight - illuminated reflectance image or other means for guiding and identification of anatomical landmarks. Carcinoma in situ has been detected by a number of these instruments.

Citation Download Citation

A E Profio "Review Of Fluorescence Diagnosis Using Porphyrins", Proc. SPIE 0907, Laser Surgery: Characterization and Therapeutics, (15 June 1988); https://doi.org/10.1117/12.945332

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