Fibre-optic photochemical stroke: generating and measuring photochemical changes inside the brain

G. Tsiminis; T. S. Klarić; E. P. Schartner; S. C. Warren-Smith; M. D. Lewis; S. A. Koblar; T. M. Monro

doi:10.1117/12.2071261

2 June 2014 Fibre-optic photochemical stroke: generating and measuring photochemical changes inside the brain

G. Tsiminis, T. S. Klarić, E. P. Schartner, S. C. Warren-Smith, M. D. Lewis, S. A. Koblar, T. M. Monro

Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 9157D4 (2014) https://doi.org/10.1117/12.2071261
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain

Abstract

We report here on the development of a method to induce a stroke in a specific location within a mouse brain through the use of an optical fibre. By capturing the emitted fluorescence signal generated using the same fibre it is then possible to monitor photochemical changes within the brain in real-time, potentially reducing the requirement for post-operative histology to determine if a stroke has successfully been induced within the animal.

Citation Download Citation

G. Tsiminis, T. S. Klarić, E. P. Schartner, S. C. Warren-Smith, M. D. Lewis, S. A. Koblar, and T. M. Monro "Fibre-optic photochemical stroke: generating and measuring photochemical changes inside the brain", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 9157D4 (2 June 2014); https://doi.org/10.1117/12.2071261

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