Low-level laser therapy promotes dendrite growth via upregulating brain-derived neurotrophic factor expression

Chengbo Meng; Zhiyong He; Da Xing

doi:10.1117/12.2068980

17 September 2014 Low-level laser therapy promotes dendrite growth via upregulating brain-derived neurotrophic factor expression

Chengbo Meng, Zhiyong He, Da Xing

Author Affiliations +

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92301G (2014) https://doi.org/10.1117/12.2068980
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Downregulation of brain-derived neurotrophic factor (BDNF) in the hippocampus occurs early in the progression of Alzheimer’s disease (AD). Since BDNF plays a critical role in neuronal survival and dendrite growth, BDNF upregulation may contribute to rescue dendrite atrophy and cell loss in AD. Low-level laser therapy (LLLT) has been demonstrated to regulate neuronal function both in vitro and in vivo. In the present study, we found that LLLT rescued neurons loss and dendritic atrophy via the increase of both BDNF mRNA and protein expression. In addition, dendrite growth was improved after LLLT, characterized by upregulation of PSD95 expression, and the increase in length, branching, and spine density of dendrites in hippocampal neurons. Together, these studies suggest that upregulation of BDNF with LLLT can ameliorate Aβ-induced neurons loss and dendritic atrophy, thus identifying a novel pathway by which LLLT protects against Aβ-induced neurotoxicity. Our research may provide a feasible therapeutic approach to control the progression of Alzheimer’s disease.

Citation Download Citation

Chengbo Meng, Zhiyong He, and Da Xing "Low-level laser therapy promotes dendrite growth via upregulating brain-derived neurotrophic factor expression", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301G (17 September 2014); https://doi.org/10.1117/12.2068980

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