Novel, near-infrared spectroscopic, label-free, techniques to assess bone abnormalities such as Paget's disease, osteoporosis and bone fractures

Diana C. Sordillo; Laura A. Sordillo; Lingyan Shi; Yury Budansky; Peter P. Sordillo M.D.; Robert R. Alfano

doi:10.1117/12.2181314

26 February 2015 Novel, near-infrared spectroscopic, label-free, techniques to assess bone abnormalities such as Paget's disease, osteoporosis and bone fractures

Diana C. Sordillo, Laura A. Sordillo, Lingyan Shi, Yury Budansky, Peter P. Sordillo M.D., Robert R. Alfano

Author Affiliations +

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 93033Z (2015) https://doi.org/10.1117/12.2181314
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Near- infrared (NIR) light with wavelengths from 650 nm to 950 nm (known as the first NIR window) has conventionally been used as a non-invasive technique that can reach deeper penetration depths through media than light at shorter wavelengths. Recently, several novel, NIR, label-free, techniques have been developed to assess Paget’s disease of bone, osteoporosis and bone microfractures. We designed a Bone Optical Analyzer (BOA) which utilizes the first window to measure changes of Hb and HbO₂. Paget’s disease is marked by an increase in vascularization in bones, and this device can enable easy diagnosis and more frequent monitoring of the patient’s condition, without exposing him to a high cumulative dose of radiation. We have also used inverse imaging algorithms to reconstruct 2D and 3D maps of the bone’s structure. This device could be used to assess diseases such as osteoporosis. Using 800 nm femtosecond excitation with two-photon (2P) microscopy, we acquired 2PM images of the periosteum and spatial frequency spectra (based on emission of collagen) from the periosteal regions. This technique can provide information on the structure of the periosteum and can detect abnormalities which may be an indication of disease. Most recently, we showed that longer NIR wavelengths in the second and third NIR windows (1100 nm-1350 nm, 1600 nm-1870 nm), could be used to image bone microfractures. Use of NIR light could allow for repeated studies in patients with diseases such as Paget’s and osteoporosis quickly and non-invasively, and could impact the current management for these diseases.

Citation Download Citation

Diana C. Sordillo, Laura A. Sordillo, Lingyan Shi, Yury Budansky, Peter P. Sordillo M.D., and Robert R. Alfano "Novel, near-infrared spectroscopic, label-free, techniques to assess bone abnormalities such as Paget's disease, osteoporosis and bone fractures", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93033Z (26 February 2015); https://doi.org/10.1117/12.2181314

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available