Photodynamic therapy application of PAMAM-porphyrin molecule on stomach cancer cells

Tugba Kiris; Mehmet Necmi Burgucu; Tugba Sagir; Mehmet Senel; Sevim Isik; Gamze Bölük-basi Ates; Hasim Ozgur Tabakoglu

doi:10.1117/12.2082731

2 March 2015 Photodynamic therapy application of PAMAM-porphyrin molecule on stomach cancer cells

Tugba Kiris, Mehmet Necmi Burgucu, Tugba Sagir, Mehmet Senel, Sevim Isik, Gamze Bölük-basi Ates, Hasim Ozgur Tabakoglu

Proceedings Volume 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV; 93080X (2015) https://doi.org/10.1117/12.2082731
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In this study, effect of a novel LED-based light source developed for 96-well-plates cell culture applications, was tried on AGS stomach cancer cell line, in combination with Poly(amido amine) (PAMAM) modified – porhyrin molecule. For each 4 generation of modified PpIX molecule 5 different concentrations tried. According to results PAMAM molecule doesnt have any photosensitizer property also didn’t show any toxic effect even if higher concentrations. Morphology and real time monitoring analysis results hold up each other and confirmed that, PpIX molecules with and without modificated high concentrations (>100μM) caused cell death via toxicicity this reason optimal concentration for PAMAM modified PpIX should be between 25 - 50 μm concentration .

Citation Download Citation

Tugba Kiris, Mehmet Necmi Burgucu, Tugba Sagir, Mehmet Senel, Sevim Isik, Gamze Bölük-basi Ates, and Hasim Ozgur Tabakoglu "Photodynamic therapy application of PAMAM-porphyrin molecule on stomach cancer cells", Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080X (2 March 2015); https://doi.org/10.1117/12.2082731

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