|
|
|
Sponsored by SPIE Cosponsored by Intuitive Surgical, Inc. (United States) LI-COR, Inc. (United States) Novadaq Technologies Inc. Published by SPIE The papers included in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. The papers published in these proceedings reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from this book: Author(s), "Title of Paper," in Molecular-Guided Surgery: Molecules, Devices, and Applications, edited by Brian W. Pogue, Sylvain Gioux, Proceedings of SPIE Vol. 9311 (SPIE, Bellingham, WA, 2015) Article CID Number. ISSN: 1605-7422 ISBN: 9781628414011 Published by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time) · Fax +1 360 647 1445 Copyright © 2015, Society of Photo-Optical Instrumentation Engineers. Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $18.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 1605-7422/15/$18.00. Printed in the United States of America. Publication of record for individual papers is online in the SPIE Digital Library. Paper Numbering: Proceedings of SPIE follow an e-First publication model, with papers published first online and then in print. Papers are published as they are submitted and meet publication criteria. A unique citation identifier (CID) number is assigned to each article at the time of the first publication. Utilization of CIDs allows articles to be fully citable as soon as they are published online, and connects the same identifier to all online, print, and electronic versions of the publication. SPIE uses a six-digit CID article numbering system in which:
The CID Number appears on each page of the manuscript. The complete citation is used on the first page, and an abbreviated version on subsequent pages. Contents
AuthorsNumbers in the index correspond to the last two digits of the six-digit citation identifier (CID) article numbering system used in Proceedings of SPIE. The first four digits reflect the volume number. Base 36 numbering is employed for the last two digits and indicates the order of articles within the volume. Numbers start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B...0Z, followed by 10-1Z, 20-2Z, etc.
Conference CommitteeSymposium Chairs
Program Track Chair Conference Chairs
Conference Program Committee
Session Chairs
IntroductionThe field of Molecular-Guided Surgery using optical techniques has been growing exponentially over the last decade, and is now recognized as one of the most promising fields that can have an impact on patient care in the near future. As such, the number and the quality of the contributions presented at the conference for its first edition were outstanding. The conference covered a wide range of topics from endogenous to exogenous contrast methods, all the way from the bench to the bedside. Every session included invited presentations from the top research groups in the world that complemented outstanding contributed presentations through the entire conference stream. Importantly, participants from different research horizons were present – mainly scientists, engineers and clinicians – and contributed to enrich the conference content by sharing their perspectives and experiences about Molecular-Guided Surgery. On the side of emerging technologies, the field is witnessing the rise of new and promising tools using endogenous molecular contrast for guiding surgery, a rising topic in the field due to its fast translational potential and its established sensitive and specific diagnostic capabilities. While it was clear that such an approach is very promising, several groups also highlighted the fact that this topic has to mature and solve significant problems related to integrating the technology into clinical workflow, and providing real-time wide-field images for macroscopic applications. These difficulties, mainly related to technology and methods, however, are balanced with the relative ease for taking imaging systems by themselves into the clinic, in a short term, due to the simplicity of the approval process as compared to methods that make use of contrast agents. Fluorescence-guided surgery has played a leading role in pulling the field forward, and both the diversity and the originality of the research clearly demonstrate its potential clinical impact. From the device side, more ergonomic tools adapted for clinical scenarios are being designed and translated into practice, with a particular emphasis on endoscopic devices, both in rigid and flexible formats. From the methods aspect, original approaches to increase the sensitivity and the specificity – such as pulsed illumination, attenuation correction or dual tracer imaging – are being developed and demonstrate promise during preclinical implementations. Finally, on the contrast agent side, the field is seeing two main parallel progresses: on one side, the use of non-specific off-label use of FDA approved contrast agents such as indocyanine green and methylene blue; and on the other, several research groups and industries are developing novel specific contrast agents. The latter is clearly the most awaited and draws significant attention and excitement, especially as these developments take place in the perspective of clinical trials and first-in-human studies, a long-standing milestone for the field of fluorescence-guided surgery to achieve. Altogether, the field of Molecular-Guided Surgery is certainly making a significant impact on the translation of optical methods to solve real clinical problems that need immediate and decisive feedback to surgeons. While both endogenous and exogenous methods exhibit distinct features and differ greatly in nature, it is anticipated that each method should be able to address niche needs in the clinic. This conference – bringing together speakers on the technology, molecules and applications – is an ideal forum in which to carry out these discussions. Brian W. Pogue Sylvain Gioux |
