High histologic grade and increased relative content of tryptophan in breast cancer using ratios from fingerprint fluorescence spectral peaks

Laura A. Sordillo; Peter P. Sordillo M.D.; Yury Budansky; Yang Pu; R. R. Alfano

doi:10.1117/12.2078414

11 March 2015 High histologic grade and increased relative content of tryptophan in breast cancer using ratios from fingerprint fluorescence spectral peaks

Laura A. Sordillo, Peter P. Sordillo M.D., Yury Budansky, Yang Pu, R. R. Alfano

Author Affiliations +

Proceedings Volume 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 931804 (2015) https://doi.org/10.1117/12.2078414
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Histologic grade is a very important, but underappreciated, parameter of breast cancer aggressiveness. Despite its importance, it has historically not been included as one of the criteria for staging of this cancer. In this study, spectral fluorescence profiles from patients with breast carcinoma were acquired. Ratios of emission peaks at 340 over 440,460 nm from biomolecules in malignant and normal samples were calculated. Cancerous over normal ratios (double ratio (DR) method) were evaluated with respect to tumor characteristics. Increased tryptophan content in breast cancer tissues correlates strongly with high grade, but not with lymph node metastases, estrogen receptor, progesterone receptor or Her-2-Neu receptor status.

Citation Download Citation

Laura A. Sordillo, Peter P. Sordillo M.D., Yury Budansky, Yang Pu, and R. R. Alfano "High histologic grade and increased relative content of tryptophan in breast cancer using ratios from fingerprint fluorescence spectral peaks", Proc. SPIE 9318, Optical Biopsy XIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 931804 (11 March 2015); https://doi.org/10.1117/12.2078414

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