Wide field OCT based microangiography in living human eye
(Conference Presentation)

Qinqin Zhang; Chieh-Li Chen; Zhongdi Chu; Anqi Zhang; Lin An; Mary Durbin; Utkarsh Sharma; Philip J. Rosenfeld; Ruikang K. Wang

doi:10.1117/12.2213097

26 April 2016 Wide field OCT based microangiography in living human eye (Conference Presentation)

Qinqin Zhang, Chieh-Li Chen, Zhongdi Chu, Anqi Zhang, Lin An, Mary Durbin, Utkarsh Sharma, Philip J. Rosenfeld, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 9693, Ophthalmic Technologies XXVI; 969303 (2016) https://doi.org/10.1117/12.2213097
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

To investigate the application of optical microangiography (OMAG) in living human eye. Patients with different macular diseases were recruited, including diabetic retinopathy (DR), geographic atrophy (GA), retinitis pigmentosa (RP), and venous occlusion, et al. Wide field OCT angiography images can be generated by montage scanning protocol based on the tracking system. OMAG algorithm based on complex differentiation was used to extract the blood flow and removed the bulk motion by 2D cross-correlation method. The 3D angiography was segmented into 3 layers in the retina and 2 layers in the choroid. The en-face maximum projection was used to obtain 2-dimensional angiograms of different layers coded with different colors. Flow and structure images were combined for cross-sectional view. En face OMAG images of different macular diseases showed a great agreement with FA. Meanwhile, OMAG gave more distinct vascular network visions that were less affected by hemorrhage and leakage. The MAs were observed in both superficial and middle retinal layers based on OMAG angiograms in different layers of DR patients. The contour line of FAZ was extracted as well, which can be quantitative the retinal diseases. For GA patient, the damage of RPE layer enhanced the penetration of light and enabled the acquisition of choriocapillaries and choroidal vessels. The wide field OMAG angiogram enabled the capability of capturing the entire geographic atrophy. OMAG provides depth-resolved information and detailed vascular images of DR and GA patients, providing a better visualization of vascular network compared to FA.

Conference Presentation

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Qinqin Zhang, Chieh-Li Chen, Zhongdi Chu, Anqi Zhang, Lin An, Mary Durbin, Utkarsh Sharma, Philip J. Rosenfeld, and Ruikang K. Wang "Wide field OCT based microangiography in living human eye (Conference Presentation)", Proc. SPIE 9693, Ophthalmic Technologies XXVI, 969303 (26 April 2016); https://doi.org/10.1117/12.2213097

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KEYWORDS

Angiography

Eye

Optical coherence tomography

Blood circulation

Detection and tracking algorithms

Image segmentation

Retina

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