Validation of coded aperture coherent scatter spectral imaging for normal and neoplastic breast tissues via surgical pathology

R. E. Morris; K. E. Albanese; M. N. Lakshmanan; S. J. McCall; J. A. Greenberg; A. J. Kapadia

doi:10.1117/12.2216974

22 March 2016 Validation of coded aperture coherent scatter spectral imaging for normal and neoplastic breast tissues via surgical pathology

R. E. Morris, K. E. Albanese, M. N. Lakshmanan, S. J. McCall, J. A. Greenberg, A. J. Kapadia

Author Affiliations +

Proceedings Volume 9783, Medical Imaging 2016: Physics of Medical Imaging; 97835T (2016) https://doi.org/10.1117/12.2216974
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

This study intends to validate the sensitivity and specificity of coded aperture coherent scatter spectral imaging (CACSSI) by comparison to standard histological preparation and pathologic analysis methods used to differentiate normal and neoplastic breast tissues. A composite overlay of the CACSSI rendered image and pathologist interpreted stained sections validate the ability of CACSSI to differentiate normal and neoplastic breast structures ex-vivo. Via comparison to pathologist annotated slides, the CACSSI system may be further optimized to maximize sensitivity and specificity for differentiation of breast carcinomas.

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R. E. Morris, K. E. Albanese, M. N. Lakshmanan, S. J. McCall, J. A. Greenberg, and A. J. Kapadia "Validation of coded aperture coherent scatter spectral imaging for normal and neoplastic breast tissues via surgical pathology", Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 97835T (22 March 2016); https://doi.org/10.1117/12.2216974

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