A suite of neurophotonics tools to access the effects of repeated blood-brain-barrier opening with focused ultrasound

Xiaojie Chen; Natalie Fomin-Thunemann; Emily Martin; Cleide Angolano; Yongzhi Zhang; Anna Devor; Martin Thunemann; Nicholas Todd

doi:10.1117/12.2610111

7 March 2022 A suite of neurophotonics tools to access the effects of repeated blood-brain-barrier opening with focused ultrasound

Xiaojie Chen, Natalie Fomin-Thunemann, Emily Martin, Cleide Angolano, Yongzhi Zhang, Anna Devor, Martin Thunemann, Nicholas Todd

Author Affiliations +

Proceedings Volume PC11946, Neural Imaging and Sensing 2022; PC119460Y (2022) https://doi.org/10.1117/12.2610111
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

Focused ultrasound (FUS) is an emerging technology for non-invasive and controlled blood-brain barrier (BBB) opening for drug delivery successfully tested in clinical trials. To improve the safety of this method, we use optical imaging techniques to better understand the relationship between repeated FUS-BBB opening, neuroinflammation, and alteration of neurovascular coupling in an animal model. We perform 1- and 2-photon microscopy in awake mice to image neuronal activity hemodynamics. Before and following FUS treatment, optical imaging sessions access changes in neuronal activity and/or hemodynamics; FUS treatments are repeated several times to approximate a clinical schedule.

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Xiaojie Chen, Natalie Fomin-Thunemann, Emily Martin, Cleide Angolano, Yongzhi Zhang, Anna Devor, Martin Thunemann, and Nicholas Todd "A suite of neurophotonics tools to access the effects of repeated blood-brain-barrier opening with focused ultrasound", Proc. SPIE PC11946, Neural Imaging and Sensing 2022, PC119460Y (7 March 2022); https://doi.org/10.1117/12.2610111

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