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In molecular photoacoustic imaging, the administration of an external photoacoustic contrast agent increases the photoacoustic yield and clarifies pathophysiological observation over the lesion site. Recognizing the necessity of a cyanine-based dye that complements the optical properties of ready-approved indocyanine green, we proceeded with molecular photoacoustic imaging in vitro and in vivo using cypate with a high absorption rate and photothermal conversion yield in the near-infrared I region. In addition, the particles are functionalized with tumor-avid peptide to facilitate receptor-based active delivery.
Donghyeon Oh,Seunghyun Lee, andChulhong Kim
"Tumor-targeted photoacoustic imaging using dimerized cyanine-based contrast agent", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600N (7 March 2022); https://doi.org/10.1117/12.2608417
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Donghyeon Oh, Seunghyun Lee, Chulhong Kim, "Tumor-targeted photoacoustic imaging using dimerized cyanine-based contrast agent," Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119600N (7 March 2022); https://doi.org/10.1117/12.2608417