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A novel photoacoustic remote sensing (PARS) microscopy architecture is presented which replaces the conventional normal-incidence back-reflected operation with independent angled-incidence excitation and collection optical pathways. This new architecture has demonstrated significant detection sensitivity improvements over normal-incidence embodiments, providing order of magnitudes reduction in sample exposure to the detection beam. The efficacy of this new architecture is explored on phantoms, bulk erythrocytes, and in vivo microvasculature. The talk will feature discussions centered around architecture design considerations and explore applications for such a device.
Kevan L. Bell andParsin Haji Reza
"Improved sensitivity with angle-incidence photoacoustic remote sensing microscopy", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602D (7 March 2022); https://doi.org/10.1117/12.2607682
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Kevan L. Bell, Parsin Haji Reza, "Improved sensitivity with angle-incidence photoacoustic remote sensing microscopy," Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602D (7 March 2022); https://doi.org/10.1117/12.2607682