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2 March 2022 Insights into nuclear mechanobiology: the central role of live cell and tissue imaging
Tanmay P. Lele
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Proceedings Volume PC11962, Optical Elastography and Tissue Biomechanics VIV; PC119620L (2022) https://doi.org/10.1117/12.2614631
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The nucleus is the largest organelle in the cell. When deformed with techniques like AFM or micropipette aspiration, the nucleus appears to be highly elastic and much stiffer than the cytoplasm. Whether the nucleus behaves like a stiff elastic object when shaped by cellular forces and on physiological time scales, such as during migration through confining channels, is not clear. Here I will discuss our efforts to understand nuclear mechanics in cell migration. I will present live cell imaging experiments that reveal surprising nuclear mechanical behaviors such as drop-like deformation. I will show how the nucleus is likely shaped by viscous coupling between the nucleus and the cytoplasm rather than static cytoskeletal stresses.
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Tanmay P. Lele "Insights into nuclear mechanobiology: the central role of live cell and tissue imaging", Proc. SPIE PC11962, Optical Elastography and Tissue Biomechanics VIV, PC119620L (2 March 2022); https://doi.org/10.1117/12.2614631
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KEYWORDS
Tissues
Live cell imaging
Atomic force microscopy
Mechanics
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