Studying vascular stenosis by high-throughput optical microscopy on a chip

Yunjie Deng; Jaime Alvarez Duque; Chengxun Su; Yuqi Zhou; Masako Nishikawa; Ting-Hui Xiao; Yutaka Yatomi; Han Wei Hou; Keisuke Goda

doi:10.1117/12.2609725

2 March 2022 Studying vascular stenosis by high-throughput optical microscopy on a chip

Yunjie Deng, Jaime Alvarez Duque, Chengxun Su, Yuqi Zhou, Masako Nishikawa, Ting-Hui Xiao, Yutaka Yatomi, Han Wei Hou, Keisuke Goda

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Proceedings Volume PC11971, High-Speed Biomedical Imaging and Spectroscopy VII; PC119710O (2022) https://doi.org/10.1117/12.2609725
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Vascular stenosis is a pathological hallmark of atherosclerosis, but its transient process is not well understood due to the lack of analytical tools to study it. Here we report spatiotemporally resolved observation of shear-induced platelet aggregation by combining a microfluidic on-chip stenosis model and optofluidic time-stretch microscopy. Our results indicate a synergistic effect of stenosis and agonists on platelet activation and aggregation. Particularly, an agonist, thrombin receptor activator peptide 6, causes preferential enhancement of platelet aggregation. Our findings are expected to deepen our understanding of stenosis-induced platelet aggregation and pave ways for developing effective antithrombotic therapeutics.

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Yunjie Deng, Jaime Alvarez Duque, Chengxun Su, Yuqi Zhou, Masako Nishikawa, Ting-Hui Xiao, Yutaka Yatomi, Han Wei Hou, and Keisuke Goda "Studying vascular stenosis by high-throughput optical microscopy on a chip", Proc. SPIE PC11971, High-Speed Biomedical Imaging and Spectroscopy VII, PC119710O (2 March 2022); https://doi.org/10.1117/12.2609725

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KEYWORDS

Microscopy

3D modeling

Blood vessels

In vitro testing

Optofluidics

Shape analysis

Statistical analysis

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