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With OCT, for the first time, the urothelial thickness change induced by water transport was observed in situ under OCT. The percentage of the change is proportional to the osmolarity of the NaCl applied to the urothelium, and different degrees of damage can be observed in histology and SEM. The observation may reveal the etiology of some highly prevalent diseases, such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB).
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Hui Wang, Lan Dao, "Urothelial response to water transport," Proc. SPIE PC12353, Advanced Photonics in Urology 2023, PC1235307 (17 March 2023); https://doi.org/10.1117/12.2648964