Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

Diana Galiakhmetova; Viktor Dremin; Aleksandr Koviarov; Dmitrii Stoliarov; Neville Ngum; Rheinallt Parri; Sergei Sokolovski; Edik Rafailov

doi:10.1117/12.2666376

6 March 2023 Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows

Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Rheinallt Parri, Sergei Sokolovski, Edik Rafailov

Author Affiliations +

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730A (2023) https://doi.org/10.1117/12.2666376
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show that the brain cortex tissues can be exposed to 10-12% of the original laser irradiation. This finding together with the latest discovery of non-linear phytochrome conversion [S.Sokolovski et al. 2021] prove the possibility of phytochrome optogenetics in living animals and may be applied in the future for non-invasive photo-controlling of neural cells.

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Diana Galiakhmetova, Viktor Dremin, Aleksandr Koviarov, Dmitrii Stoliarov, Neville Ngum, Rheinallt Parri, Sergei Sokolovski, and Edik Rafailov "Ultrashort pulsed laser in deep head tissues penetration for non-invasive optogenetics in near-IR windows", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730A (6 March 2023); https://doi.org/10.1117/12.2666376

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KEYWORDS

Pulsed laser operation

Optogenetics

Tissues

Head

Windows

Brain

Skin

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