Towards in-vivo monitoring of disease progression of inflammatory arthritis in rodent models using fibre-optic Raman spectroscopy

Anders R. Walther; Elzbieta Stepula; Nicholas Ditzel; Moustapha Kassem; Mads S. Bergholt; Martin A. B. Hedegaard

doi:10.1117/12.2647619

6 March 2023 Towards in-vivo monitoring of disease progression of inflammatory arthritis in rodent models using fibre-optic Raman spectroscopy

Anders R. Walther, Elzbieta Stepula, Nicholas Ditzel, Moustapha Kassem, Mads S. Bergholt, Martin A. B. Hedegaard

Author Affiliations +

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730G (2023) https://doi.org/10.1117/12.2647619
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder characterized by synovial inflammation and pannus formation leading to destruction of local articular structure, bone erosion and functional disabilities. Common research models of inflammatory arthritis in rodents e.g. collagen antibody-induced arthritis (CAIA) in mice are associated with pain, discomfort, and distress. Here we demonstrate in vivo assessment of CAIA mice using a transflection Raman setup. Mice with induced arthritis and controls were clinically and spectroscopically assessed for 14 days. Raman measurements of tibiotarsal joint bone density correlated well with volumetric bone mineral density (vBMD) in mice exhibiting clinical symptoms of arthritis.

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Anders R. Walther, Elzbieta Stepula, Nicholas Ditzel, Moustapha Kassem, Mads S. Bergholt, and Martin A. B. Hedegaard "Towards in-vivo monitoring of disease progression of inflammatory arthritis in rodent models using fibre-optic Raman spectroscopy", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730G (6 March 2023); https://doi.org/10.1117/12.2647619

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