Multiplexed detection of cancer biomarkers using inverse molecular sentinel integrated on plasmonic bimetallic nanostar substrate (Conference Presentation)

Aidan Canning; Xinrong Chen; Hsin-Neng Wang; Tuan Vo-Dinh

doi:10.1117/12.2650723

16 March 2023 Multiplexed detection of cancer biomarkers using inverse molecular sentinel integrated on plasmonic bimetallic nanostar substrate (Conference Presentation)

Aidan Canning, Xinrong Chen, Hsin-Neng Wang, Tuan Vo-Dinh

Author Affiliations +

Proceedings Volume PC12396, Plasmonics in Biology and Medicine XX; PC1239603 (2023) https://doi.org/10.1117/12.2650723
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present the integration of a miRNA sensing probe technology with a bimetallic nanostar-based surfaced-enhanced Raman scattering (SERS) substrate for disease detection. Circulating microRNAs (miRNA) are being investigated as promising diagnostic biomarkers for many cancers, including colorectal cancer (CRC). The inverse molecular sentinel technology was used for amplification-free multiplexed detection of miRNA targets using SERS. The integration of these technologies lays the foundation for point of care device design, capable of miRNA profiling without the need for traditional sample preparation of nucleotide amplification techniques.

Conference Presentation

Citation Download Citation

Aidan Canning, Xinrong Chen, Hsin-Neng Wang, and Tuan Vo-Dinh "Multiplexed detection of cancer biomarkers using inverse molecular sentinel integrated on plasmonic bimetallic nanostar substrate (Conference Presentation)", Proc. SPIE PC12396, Plasmonics in Biology and Medicine XX, PC1239603 (16 March 2023); https://doi.org/10.1117/12.2650723

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