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We report the incorporation of porous silicon on paper towards the realization of a low-cost rapid diagnostic testing platform with the capability for quantification of detected molecules. Real-time optical reflectance measurements of bovine serum albumin adsorption were carried out to benchmark the sensor. Simulations and experiments demonstrate a response-time dependence on porous silicon pore size. Approaches to overcome challenges with porous silicon adhesion on paper and porous silicon membrane mechanical robustness will be discussed.
Rabeb Layouni,Juliana Yang,Simon J. Ward,Paul E. Laibinis, andSharon M. Weiss
"Paper-based diagnostics incorporating porous silicon (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC123970B (17 March 2023); https://doi.org/10.1117/12.2653126
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Rabeb Layouni, Juliana Yang, Simon J. Ward, Paul E. Laibinis, Sharon M. Weiss, "Paper-based diagnostics incorporating porous silicon (Conference Presentation)," Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC123970B (17 March 2023); https://doi.org/10.1117/12.2653126