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6 October 2023 A protocol for THz-ATR spectroscopy-based detection of mimicked interstitial fluid in ex vivo skin: towards ML-reinforced THz biosensing
Lorenza P. Foglia, Bjørn H. Mølvig, Mads Erhorn, Miriam Galbiati, Simon J. Lange, Peter U. Jepsen
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Proceedings Volume PC12683, Terahertz Emitters, Receivers, and Applications XIV; PC126830I (2023) https://doi.org/10.1117/12.2681885
Event: SPIE Optical Engineering + Applications, 2023, San Diego, California, United States
Abstract
The skin's interstitial fluid is rich in composition and easily accessible for the monitoring of systemic biomarkers, however, THz-based molecular detection in biological media is challenging. Machine learning can provide solutions, but strict data engineering is required to avoid confounding trends and ensure large training datasets. We propose an experimental framework to mimic interstitial fluid diffusion in ex vivo pig skin to detect analytes via THz-ATR spectroscopy. We evaluate the applicability of the protocol for controlled studies of THz-ATR spectroscopy-based biomolecular detection in skin. Our findings can significantly contribute to the field of ML-reinforced biosensing.
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Lorenza P. Foglia, Bjørn H. Mølvig, Mads Erhorn, Miriam Galbiati, Simon J. Lange, and Peter U. Jepsen "A protocol for THz-ATR spectroscopy-based detection of mimicked interstitial fluid in ex vivo skin: towards ML-reinforced THz biosensing", Proc. SPIE PC12683, Terahertz Emitters, Receivers, and Applications XIV, PC126830I (6 October 2023); https://doi.org/10.1117/12.2681885
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KEYWORDS
Skin
Spectroscopy
Biosensing
Terahertz radiation
Biomolecules
Data modeling
Diffusion
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