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19 March 2024 Dual color, high resolution 2P autofluorescence imaging probe with custom designed excitation optics
Berk Camli, Aditya Roy, Biswajit Mishra, Liam P. Andrus, Chris Xu, Irene Georgakoudi, Tomasz S. Tkaczyk, Adela Ben-Yakar
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Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC1282009 (2024) https://doi.org/10.1117/12.3001642
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We extend the resolution of our 2p autofluorescence imaging probe by incorporation of custom designed and fabricated optics. We will add an NA extender piece, inserted at excitation fiber tip to boost the beam divergence at the excitation optics input. The new custom designed miniaturized objective will achieve a resolution of 0.5 μm, without any changes to the diameter of the objective design. Custom design objective also will allow us to perform autofluorescence imaging at two colors. This will enable the optical redox ratio characterization of tissues, which is an important hallmark in diagnosis of cancers at early stages.
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Berk Camli, Aditya Roy, Biswajit Mishra, Liam P. Andrus, Chris Xu, Irene Georgakoudi, Tomasz S. Tkaczyk, and Adela Ben-Yakar "Dual color, high resolution 2P autofluorescence imaging probe with custom designed excitation optics", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282009 (19 March 2024); https://doi.org/10.1117/12.3001642
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KEYWORDS
Auto-fluorescence imaging
Image resolution
Tissue optics
Optical design
Tissues
Design and modelling
Cancer
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