A novel capsule endoscope for immuno-OCT imaging in the gastrointestinal tract

Tyla Danskin; Andrea J. Sterkenburg; Wouter B. Nagengast; Johannes F. de Boer

doi:10.1117/12.3003001

13 March 2024 A novel capsule endoscope for immuno-OCT imaging in the gastrointestinal tract

Tyla Danskin, Andrea J. Sterkenburg, Wouter B. Nagengast, Johannes F. de Boer

Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC128200C (2024) https://doi.org/10.1117/12.3003001
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Optical Coherence Tomography (OCT) acquires micron-resolution depth information on the superficial layers of tissues, but lacks in molecular specificity. Near Infrared Fluorescence (NIRF) imaging in combination with fluorescently labelled monoclonal antibodies can provide micron-resolution molecular contrast (Immuno-OCT). Here, a novel capsule endoscope design is presented, which facilitates circumferential imaging in the gastrointestinal tract. The endoscope is fitted with a double clad fiber coupler to enable dual-modality imaging. We present preliminary endoscopic data for both imaging modalities, for which phantoms were used to validate the capsule endoscope as an Immuno-OCT imaging device.

Conference Presentation

Citation Download Citation

Tyla Danskin, Andrea J. Sterkenburg, Wouter B. Nagengast, and Johannes F. de Boer "A novel capsule endoscope for immuno-OCT imaging in the gastrointestinal tract", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC128200C (13 March 2024); https://doi.org/10.1117/12.3003001

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