Novel dual antimicrobial-imaging photodynamic therapy agent labels and kills AMR gram-positive bacteria

Alex Kiang; Sam Benson; Charles Lochenie; Sheelagh Duncan; Syam Mohan P. C. Mohanan; Gareth O. S. Williams; Kevin Dhaliwal; Marc Vendrell; Beth Mills

doi:10.1117/12.3001408

13 March 2024 Novel dual antimicrobial-imaging photodynamic therapy agent labels and kills AMR gram-positive bacteria

Alex Kiang, Sam Benson, Charles Lochenie, Sheelagh Duncan, Syam Mohan P. C. Mohanan, Gareth O. S. Williams, Kevin Dhaliwal, Marc Vendrell, Beth Mills

Author Affiliations +

Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC1282207 (2024) https://doi.org/10.1117/12.3001408
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Novel dual imaging-antimicrobial photodynamic therapy probe SeNBD-van is a promising alternative to conventional antibiotics in the treatment against gram-positive bacteria. It successfully labels and identifies gram-positive bacteria and is capable of selectively killing such bacteria, even those with existing multi-resistances to antibiotics in as little at 20 min. It maintains its high efficacy even in complex environments such as biofilms and skin models, demonstrating great value and potential as an alternative to current methods of management of infections.

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Citation Download Citation

Alex Kiang, Sam Benson, Charles Lochenie, Sheelagh Duncan, Syam Mohan P. C. Mohanan, Gareth O. S. Williams, Kevin Dhaliwal, Marc Vendrell, and Beth Mills "Novel dual antimicrobial-imaging photodynamic therapy agent labels and kills AMR gram-positive bacteria", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC1282207 (13 March 2024); https://doi.org/10.1117/12.3001408

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