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13 March 2024 A novel acquired resistance mechanism to to ALA-PDT with ABCG2 inhibition
Sharayu Chandratre, Bin Chen
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC1282304 (2024) https://doi.org/10.1117/12.2692654
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The efficacy of ALA PDT in targeting tumour cells depends on the extent of PpIX accumulation at the target site. Targeting PpIX bioconversion enzyme FeCH and efflux transporter ABCG2 helps overcome intrinsic resistance to the therapy. However, the factors contributing to the development of acquired resistance to PDT are lesser known. Here we show that repeated exposure to ALA PDT results in the downregulation of PpIX biosynthetic machinery to a greater extent compared to the PpIX bioconversion by FeCH or its efflux by ABCG2. Overall, this study highlights the mechanisms involved in the development of acquired resistance to ALA PDT in tumour cell lines.
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Sharayu Chandratre and Bin Chen "A novel acquired resistance mechanism to to ALA-PDT with ABCG2 inhibition", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC1282304 (13 March 2024); https://doi.org/10.1117/12.2692654
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KEYWORDS
Resistance
Photodynamic therapy
Cancer
Fluorescence
Biomedical applications
Cell death
Fluorescence imaging
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