Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery

Frédéric Leblond; Sandryne David; Samaneh Pahlavani; Nassim Ksantini; Frédérick Dallaire; Guillaume Sheehy; Costas Hadjapanayis; Kevin Petrecca; Brian C. Wilson

doi:10.1117/12.3001248

13 March 2024 Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery

Frédéric Leblond, Sandryne David, Samaneh Pahlavani, Nassim Ksantini, Frédérick Dallaire, Guillaume Sheehy, Costas Hadjapanayis, Kevin Petrecca, Brian C. Wilson

Author Affiliations +

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC1282505 (2024) https://doi.org/10.1117/12.3001248
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This research introduces a new approach based on Raman spectroscopy for quickly and effectively detecting brain tumors at a macroscopic scale, making it suitable for intra-operative use. By focusing on a specific vibrational band at 1440 cm-1 as a cancer biomarker, this method will enable rapid imaging of a field of view spanning several centimeters in approximately 5 seconds. The results of this study demonstrated high sensitivity/specificity for meningioma (97%/95%), brain metastases (95%/91%), and glioblastoma (78%/84%). The performance of this developed imaging system was compared to a custom hyperspectral line-scanning Raman system as the gold standard.

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Frédéric Leblond, Sandryne David, Samaneh Pahlavani, Nassim Ksantini, Frédérick Dallaire, Guillaume Sheehy, Costas Hadjapanayis, Kevin Petrecca, and Brian C. Wilson "Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC1282505 (13 March 2024); https://doi.org/10.1117/12.3001248

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KEYWORDS

Imaging spectroscopy

Raman spectroscopy

Cancer detection

Brain

Brain cancer

Surgery

Cancer

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