Danny F. Xie,1 Christian Crouzet,1 Chuo Fang,1 Han Liu,1 Jihua Liu,1 Donghy Lee,1 Adrian Vallejo,1 Annlia Paganini-Hill,1 Wei Ling Lau,1 David Cribbs,1 Mark Fisher,1 Bernard Choi1
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The cerebral vasculature facilitates blood flow to maintain normal function in the brain. Vascular injury can impair the ability of the cerebral vasculature to regulate blood flow and preserve the integrity of the blood-brain barrier. Cerebral microhemorrhages (CMH) are an indicator of structural damage in the brain vasculature. Aging and hypertension are the most common risk factors for CMH. In this study, we analyzed the effect of hypertension on resting-state cerebral blood flow and the development of CMH in a mouse model of aging. A reduction in resting-state cerebral blood flow was observed in hypertension mice. CMH were found to appear nearest to capillary-sized vessels. Together, these findings demonstrate hypertension can impair the function (via reduced resting-state cerebral blood flow) and structure (via formation of CMH) of the brain vasculature.
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Danny F. Xie, Christian Crouzet, Chuo Fang, Han Liu, Jihua Liu, Donghy Lee, Adrian Vallejo, Annlia Paganini-Hill, Wei Ling Lau, David Cribbs, Mark Fisher, Bernard Choi, "Hypertension provokes the development of cerebral microhemorrhages and vascular injury in a mouse model," Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280J (13 March 2024); https://doi.org/10.1117/12.3002206