Evaluation of human kidney for transplantation using polarization-sensitive optical coherence tomography

Feng Yan; Chen Wang; Bornface M. Mutembei; Zaid A. Alhajeri; Qinghao Zhang; Ebenezer Raj Selvarai Mercyshalinie; Zhongxin Yu; Yu Chen; Kar-Ming Fung; Qinggong Tang

doi:10.1117/12.3001968

13 March 2024 Evaluation of human kidney for transplantation using polarization-sensitive optical coherence tomography

Feng Yan, Chen Wang, Bornface M. Mutembei, Zaid A. Alhajeri, Qinghao Zhang, Ebenezer Raj Selvarai Mercyshalinie, Zhongxin Yu, Yu Chen, Kar-Ming Fung, Qinggong Tang

Author Affiliations +

Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC1283404 (2024) https://doi.org/10.1117/12.3001968
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Kidney transplantation faces a worldwide shortage due to the lack of reliable assessment for screening qualified donor kidneys for transplantation. We evaluated the feasibility of using polarization-sensitive optical coherence tomography (PS-OCT) to provide a score map covering the entire surface of a kidney to evaluate the pre-transplantation kidney quality. Multiple histology staining and two-photon microscopy (TPM) were used to provide verification standards for microstructures, tissue distributions, and fibrosis in PS-OCT imaging. Our results indicated that PS-OCT was a reliable method for noninvasively imaging kidney microstructure and fibrosis matching the pretransplant scoring system for assessing the quality of pre-transplantation kidneys.

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Feng Yan, Chen Wang, Bornface M. Mutembei, Zaid A. Alhajeri, Qinghao Zhang, Ebenezer Raj Selvarai Mercyshalinie, Zhongxin Yu, Yu Chen, Kar-Ming Fung, and Qinggong Tang "Evaluation of human kidney for transplantation using polarization-sensitive optical coherence tomography", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC1283404 (13 March 2024); https://doi.org/10.1117/12.3001968

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