Ultrasound-guided photoacoustic functional imaging to assess regional response to receptor tyrosine kinase inhibitor therapies

Srivalleesha Mallidi; Allison Sweeney; Andrew Langley; Patrick Solomon

doi:10.1117/12.3003456

13 March 2024 Ultrasound-guided photoacoustic functional imaging to assess regional response to receptor tyrosine kinase inhibitor therapies

Srivalleesha Mallidi, Allison Sweeney, Andrew Langley, Patrick Solomon

Author Affiliations +

Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC1283408 (2024) https://doi.org/10.1117/12.3003456
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this work, murine xenografts of pancreatic cancer cell lines AsPC-1 and Mia PaCa-2 were used to investigate vascularization, oxygenation, and the effect of sunitinib treatment on pancreatic cancer. Ultrasound-guided photoacoustic imaging (US-PAI) at multiple wavelengths was utilized to study the tumor vascular networks, throughout the receptor tyrosine kinase inhibitor sunitinib treatment. The 3D photoacoustic data was fluence compensated and spectrally unmixed to acquire the parameters of blood oxygen saturation (StO2) and total hemoglobin concentration (HbT). A custom regional segmentation algorithm was applied to the volumetric HbT images to segment the tumor volume into areas of high vascular density and low vascular density. Regionally evaluating the changes in StO2 and HbT reveals that sunitinib is preferentially targeting areas of low vascular density.

Conference Presentation

Citation Download Citation

Srivalleesha Mallidi, Allison Sweeney, Andrew Langley, and Patrick Solomon "Ultrasound-guided photoacoustic functional imaging to assess regional response to receptor tyrosine kinase inhibitor therapies", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC1283408 (13 March 2024); https://doi.org/10.1117/12.3003456

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