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13 March 2024 Deep blood flow extraction for diffuse correlation spectroscopy at photon-starved regimes using SPAD arrays
Melissa M. Wu, Lucas Kreiss, Michael A. Wayne, Mitchell B. Robinson, Claudio Bruschini, Edoardo Charbon, Roarke Horstmeyer
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Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC128410B (2024) https://doi.org/10.1117/12.3001940
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Diffuse correlation spectroscopy (DCS) is an optical technique that allows for non-invasive measurements of tissue perfusion, and is often used for neuromonitoring applications. However, a major challenge of DCS is low SNR for deep tissue measurements. Recent works have demonstrated the potential for SPAD arrays to provide significant SNR increases by averaging autocorrelation signals from individual speckles. Such methods may still be suboptimal for efficient signal extraction, as the individual signals may each be low fidelity. In this work, we explore alternative methods of integrating parallelized DCS signals in low photon regimes for accurate blood flow estimation.
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Melissa M. Wu, Lucas Kreiss, Michael A. Wayne, Mitchell B. Robinson, Claudio Bruschini, Edoardo Charbon, and Roarke Horstmeyer "Deep blood flow extraction for diffuse correlation spectroscopy at photon-starved regimes using SPAD arrays", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC128410B (13 March 2024); https://doi.org/10.1117/12.3001940
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KEYWORDS
Spectroscopy
Blood circulation
Autocorrelation
Speckle
Source detector separation
Fluorescence correlation spectroscopy
In vivo imaging
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