Visual-evoked hemodynamic responses in the mouse brain observed through a 1-D CMUT array in photoacoustic imaging

Kai-Wei Chang; Ermek Belekov; Xueding Wang; Omer Oralkan; Guan Xu

doi:10.1117/12.3001915

13 March 2024 Visual-evoked hemodynamic responses in the mouse brain observed through a 1-D CMUT array in photoacoustic imaging

Kai-Wei Chang, Ermek Belekov, Xueding Wang, Omer Oralkan, Guan Xu

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC128420P (2024) https://doi.org/10.1117/12.3001915
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Our research utilizes capacitive micromachined ultrasonic transducers (CMUTs) for advanced photoacoustic (PA) and ultrasound (US) imaging in mice, focusing on visual-evoked hemodynamic responses. CMUTs exhibit superior sensitivity and wider bandwidth than traditional PZT arrays, enabling improved spatial resolution and image quality. Preliminary tests of a 1-D CMUT array demonstrated its potential in capturing hemodynamic responses in the primary visual cortex (V1) and superior colliculus (SC) during retinal photostimulation. With its impressive performance and miniaturization potential, CMUTs show promise for future applications in studying visual responses in transgenic mice and disease models without the need for anesthesia or restraint.

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Citation Download Citation

Kai-Wei Chang, Ermek Belekov, Xueding Wang, Omer Oralkan, and Guan Xu "Visual-evoked hemodynamic responses in the mouse brain observed through a 1-D CMUT array in photoacoustic imaging", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC128420P (13 March 2024); https://doi.org/10.1117/12.3001915

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KEYWORDS

Imaging arrays

Hemodynamics

Photoacoustic imaging

Visualization

Brain

Ferroelectric materials

Neuroimaging

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