Investigation of pregnant mice cervix remodeling with a self validating Mueller matrix micro-mesoscope (SAMMM)

JunZhu Pei; Jessica Ramella-Roman; Ajmal Ajmal; Tananant Boonya-Ananta

doi:10.1117/12.3005362

13 March 2024 Investigation of pregnant mice cervix remodeling with a self validating Mueller matrix micro-mesoscope (SAMMM)

JunZhu Pei, Jessica Ramella-Roman, Ajmal Ajmal, Tananant Boonya-Ananta

Author Affiliations +

Proceedings Volume PC12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024; PC1284507 (2024) https://doi.org/10.1117/12.3005362
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Preterm birth (PTB) is a critical global health concern, contributing to over 35% of 3.1 million neonatal deaths annually. PTB is linked to various developmental complications, including neurological disorders, cognitive impairment, and gestational difficulties. Our primary objective in this study is to investigate pregnant cervix remodeling using the Self Validating Mueller Matrix Micro-mesoscope (SAMMM). Departing from conventional methods, our research emphasizes visualizing the entire cervix through large field of view mesoscopic imaging and high-resolution microscopic imaging. By employing SAMMM, we aim to visualize the extracellular matrix (ECM) structure in spatially defined cervical sections, from the internal os to the distal cervix, at different gestational stages in mice. This research has significant potential to improve PTB risk assessment and maternal-neonatal healthcare outcomes on a global scale, contributing to enhanced understanding and targeted interventions for better maternal and neonatal health.

Conference Presentation

Citation Download Citation

JunZhu Pei, Jessica Ramella-Roman, Ajmal Ajmal, and Tananant Boonya-Ananta "Investigation of pregnant mice cervix remodeling with a self validating Mueller matrix micro-mesoscope (SAMMM)", Proc. SPIE PC12845, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2024, PC1284507 (13 March 2024); https://doi.org/10.1117/12.3005362

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available