Radiobiological animal studies with laser-accelerated particle beams

Florian Kroll

doi:10.1117/12.3012942

11 April 2024 Radiobiological animal studies with laser-accelerated particle beams

Florian Kroll

Proceedings Volume PC12939, High-Power Laser Ablation VIII; PC1293913 (2024) https://doi.org/10.1117/12.3012942
Event: SPIE High-Power Laser Ablation, 2024, Santa Fe, New Mexico, United States

Abstract

Laser-plasma acceleration (LPA) sources exhibit extraordinary beam properties that create unique application opportunities but also pose challenges. LPA can generate energetic ions or electrons. The resulting bunches feature a high number of particles concentrated in temporally short bunches, making them capable of delivering ultra-high dose rates (UHDR), e.g., for radiobiological research. However, LPA sources suffer from unfavorable beam properties such as shot-to-shot fluctuation, high divergence, and a broad energy distribution. The presentation focuses on results obtained at the Draco PW laser facility. Draco PW drives an LPA proton source that was stabilized by tuning the laser’s spectral phase. Pulsed high-field magnets efficiently tailor the beam to meet the demands of application experiments, here, the world’s first radiobiological animal studies with laser-accelerated particle beams (zebrafish embryos and tumors in a mouse model). The role of LPA particle sources in the context of UHDR radiobiology and FLASH radiotherapy – possibly the next breakthrough in the fight against cancer – will be discussed.

Conference Presentation

Citation Download Citation

Florian Kroll "Radiobiological animal studies with laser-accelerated particle beams", Proc. SPIE PC12939, High-Power Laser Ablation VIII, PC1293913 (11 April 2024); https://doi.org/10.1117/12.3012942

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