Rare-earth-doped nanoparticles (REDNs), initially used as an alternative to quantum dots (QDs), along with commercially available organic dyes, have emerged as versatile nanoprobes with biocompatibility and tunability extending to the short-wavelength infrared (SWIR) optical window (~1000– 2500 nm). Conventionally, REDNs rely on upconversion (UC)—the ability to convert low photon energy [e.g., near-infrared (NIR) or SWIR light] into high photon energy (e.g., visible light)—for biomedical optical applications.
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