Short-Wave Infrared Meso-Patterned Imaging for Quantitative and Label-Free Tissue Characterization

Zhao, Yanyu, Beihang Univ.; Pilvar, Anahita, Boston Univ.; Pierce, Mark C., Rutgers, The State Univ. of New Jersey; Roblyer, Darren M., Boston Univ.

doi:10.1117/3.2604326.ch4

Book: Short-Wavelength Infrared Windows for Biomedical Applications

Editor(s): Laura A. Sordillo; Peter P. Sordillo

Author(s): Yanyu Zhao, Anahita Pilvar, Mark Pierce, Darren Roblyer

Published: 2021

https://doi.org/10.1117/3.2604326.ch4

Author Affiliations +

Abstract

Tissue optical absorption is related to the abundance of tissue chromophores— such as oxyhemoglobin, deoxyhemoglobin, melanin, collagen, elastin, water, and lipids. Optical scattering is related to the size and distribution of so-called scattering centers in tissue, at cellular and subcellular scales. Noninvasive assessment of these optical properties in tissues may enable diagnosis and treatment monitoring of many health conditions, but quantitative in vivo measurements of μ_a and μ_s^Ι are intrinsically challenging due to the confounding effects of absorption and scattering on overall optical attenuation.