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1 July 2008 Changes in optical properties of tissue during acute wound healing in an animal model
Elisabeth S. Papazoglou, Michael S. Weingarten M.D., Leonid Zubkov, Michael T. Neidrauer, Linda S. Zhu, Som D. Tyagi, Kambiz Pourrezaei
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Journal of Biomedical Optics, Vol. 13, Issue 4, 044005 (July 2008). https://doi.org/10.1117/1.2960952
Abstract
Changes of optical properties of wound tissue in hairless rats were quantified by diffuse photon density wave methodology at near-infrared frequencies. The diffusion equation for semi-infinite media was used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain device. There was an increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared with the nonwounded sites. The changes correlated with the healing stage of the wound. The data obtained were supported by immunohistochemical analysis of wound tissue. These results verified now by two independent animal studies could suggest a noninvasive method to detect the progress of wound healing.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Elisabeth S. Papazoglou, Michael S. Weingarten M.D., Leonid Zubkov, Michael T. Neidrauer, Linda S. Zhu, Som D. Tyagi, and Kambiz Pourrezaei "Changes in optical properties of tissue during acute wound healing in an animal model," Journal of Biomedical Optics 13(4), 044005 (1 July 2008). https://doi.org/10.1117/1.2960952
Published: 1 July 2008
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Cited by 22 scholarly publications and 1 patent.
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KEYWORDS
Wound healing
Tissue optics
Optical properties
Absorption
Animal model studies
Near infrared spectroscopy
Tissues
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