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5 November 2013 Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability
Cheng Wang, Ruping Liu, Wei Zhang, Yujian Wang, Kai Xu, Zhao Yue, Guohua Liu
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Journal of Biomedical Optics, Vol. 18, Issue 11, 115002 (November 2013). https://doi.org/10.1117/1.JBO.18.11.115002
Abstract
An on-chip spectral surface plasmon resonance (SPR) biosensor with three parallel channels has been built for biomolecule detections. It is capable of updating intensity baselines to suppress errors induced by light source instability. In order to minimize structure and reduce positional regression uncertainty, the scan operations are achieved by timely changing optical media instead of conventional mechanical scan. The detection results of human immunoglobulin G (hIgG) demonstrated that the baseline updating improves the limitation of detection of hIgG concentration from ∼86.1 to ∼17.4  ng/mL.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Cheng Wang, Ruping Liu, Wei Zhang, Yujian Wang, Kai Xu, Zhao Yue, and Guohua Liu "Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability," Journal of Biomedical Optics 18(11), 115002 (5 November 2013). https://doi.org/10.1117/1.JBO.18.11.115002
Published: 5 November 2013
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Cited by 9 scholarly publications.
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KEYWORDS
Liquids
Surface plasmons
Biomedical optics
Gold
Light sources
Glasses
Biological research
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