Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit

Jing Xu; Kevin Wong; Yifan Jian; Marinko V. Sarunic

doi:10.1117/1.JBO.19.2.026001

6 February 2014 Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit

Jing Xu, Kevin Wong, Yifan Jian, Marinko V. Sarunic

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Journal of Biomedical Optics, Vol. 19, Issue 2, 026001 (February 2014). https://doi.org/10.1117/1.JBO.19.2.026001

Abstract

In this report, we describe a graphics processing unit (GPU)-accelerated processing platform for real-time acquisition and display of flow contrast images with Fourier domain optical coherence tomography (FDOCT) in mouse and human eyes in vivo. Motion contrast from blood flow is processed using the speckle variance OCT (svOCT) technique, which relies on the acquisition of multiple B-scan frames at the same location and tracking the change of the speckle pattern. Real-time mouse and human retinal imaging using two different custom-built OCT systems with processing and display performed on GPU are presented with an in-depth analysis of performance metrics. The display output included structural OCT data, en face projections of the intensity data, and the svOCT en face projections of retinal microvasculature; these results compare projections with and without speckle variance in the different retinal layers to reveal significant contrast improvements. As a demonstration, videos of real-time svOCT for in vivo human and mouse retinal imaging are included in our results. The capability of performing real-time svOCT imaging of the retinal vasculature may be a useful tool in a clinical environment for monitoring disease-related pathological changes in the microcirculation such as diabetic retinopathy.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jing Xu, Kevin Wong, Yifan Jian, and Marinko V. Sarunic "Real-time acquisition and display of flow contrast using speckle variance optical coherence tomography in a graphics processing unit," Journal of Biomedical Optics 19(2), 026001 (6 February 2014). https://doi.org/10.1117/1.JBO.19.2.026001

Published: 6 February 2014

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