Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography

Kelly E. Michaelsen; Venkataramanan Krishnaswamy; Adele Shenoy; Emily Jordan; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/1.JBO.19.2.026012

18 February 2014 Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography

Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Adele Shenoy, Emily Jordan, Brian W. Pogue, Keith D. Paulsen

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Journal of Biomedical Optics, Vol. 19, Issue 2, 026012 (February 2014). https://doi.org/10.1117/1.JBO.19.2.026012

Abstract

Breast mimicking tissue optical phantoms with sufficient structural integrity to be deployed as stand-alone imaging targets are developed and successfully constructed with biologically relevant concentrations of water, lipid, and blood. The results show excellent material homogeneity and reproducibility with inter- and intraphantom variability of 3.5 and 3.8%, respectively, for water and lipid concentrations ranging from 15 to 85%. The phantoms were long-lasting and exhibited water and lipid fractions that were consistent to within 5% of their original content when measured 2 weeks after creation. A breast-shaped three-compartment model of adipose, fibroglandular, and malignant tissues was created with water content ranging from 30% for the adipose simulant to 80% for the tumor. Mean measured water content ranged from 30% in simulated adipose to 73% in simulated tumor with the higher water localized to the tumor-like material. This novel heterogeneous phantom design is composed of physiologically relevant concentrations of the major optical absorbers in the breast in the near-infrared wavelengths that should significantly improve imaging system characterization and optimization because the materials have stand-alone structural integrity and can be readily molded into the sizes and shapes of tissues commensurate with clinical breast imaging.

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Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Adele Shenoy, Emily Jordan, Brian W. Pogue, and Keith D. Paulsen "Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography," Journal of Biomedical Optics 19(2), 026012 (18 February 2014). https://doi.org/10.1117/1.JBO.19.2.026012

Published: 18 February 2014

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