Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization

Umar S. Alqasemi; Hai Li; Guangqian Yuan; Patrick D. Kumavor; Saeid Zanganeh; Quing Zhu

doi:10.1117/1.JBO.19.7.076020

28 July 2014 Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization

Umar S. Alqasemi, Hai Li, Guangqian Yuan, Patrick D. Kumavor, Saeid Zanganeh, Quing Zhu

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 7, 076020 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076020

Abstract

Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.

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Umar S. Alqasemi, Hai Li, Guangqian Yuan, Patrick D. Kumavor, Saeid Zanganeh, and Quing Zhu "Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization," Journal of Biomedical Optics 19(7), 076020 (28 July 2014). https://doi.org/10.1117/1.JBO.19.7.076020

Published: 28 July 2014

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KEYWORDS

Acquisition tracking and pointing

Imaging systems

Field programmable gate arrays

Ovary

Tumors

Ultrasonography

Tissue optics

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