Optical imaging of hemoglobin oxygen saturation using a small number of spectral images for endoscopic application

Takaaki Saito; Hiroshi Yamaguchi

doi:10.1117/1.JBO.20.12.126011

23 December 2015 Optical imaging of hemoglobin oxygen saturation using a small number of spectral images for endoscopic application

Takaaki Saito, Hiroshi Yamaguchi

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Journal of Biomedical Optics, Vol. 20, Issue 12, 126011 (December 2015). https://doi.org/10.1117/1.JBO.20.12.126011

Abstract

Tissue hypoxia is associated with tumor and inflammatory diseases, and detection of hypoxia is potentially useful for their detailed diagnosis. An endoscope system that can optically observe hemoglobin oxygen saturation (StO₂) would enable minimally invasive, real-time detection of lesion hypoxia in vivo. Currently, point measurement of tissue StO₂ via endoscopy is possible using the commercial fiber-optic oximeter T-Stat, which is based on visible light spectroscopy at many wavelengths. For clinical use, however, imaging of StO₂ is desirable to assess the distribution of tissue oxygenation around a lesion. Here, we describe our StO₂ imaging technique based on a small number of wavelength ranges in the visible range. By assuming a homogeneous tissue, we demonstrated that tissue StO₂ can be obtained independently from the scattering property and blood concentration of tissue using four spectral bands. We developed a prototype endoscope system and used it to observe tissue-simulating phantoms. The StO₂ (%) values obtained using our technique agreed with those from the T-Stat within 10%. We also showed that tissue StO₂ can be derived using three spectral band if the scattering property is fixed at preliminarily measured values.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Takaaki Saito and Hiroshi Yamaguchi "Optical imaging of hemoglobin oxygen saturation using a small number of spectral images for endoscopic application," Journal of Biomedical Optics 20(12), 126011 (23 December 2015). https://doi.org/10.1117/1.JBO.20.12.126011

Published: 23 December 2015

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