Transurethral light delivery for prostate photoacoustic imaging

Muyinatu A. Lediju Bell; Xiaoyu Guo; Danny Y. Song; Emad M. Boctor

doi:10.1117/1.JBO.20.3.036002

2 March 2015 Transurethral light delivery for prostate photoacoustic imaging

Muyinatu A. Lediju Bell, Xiaoyu Guo, Danny Y. Song, Emad M. Boctor

Author Affiliations +

Journal of Biomedical Optics, Vol. 20, Issue 3, 036002 (March 2015). https://doi.org/10.1117/1.JBO.20.3.036002

Abstract

Photoacoustic imaging has broad clinical potential to enhance prostate cancer detection and treatment, yet it is challenged by the lack of minimally invasive, deeply penetrating light delivery methods that provide sufficient visualization of targets (e.g., tumors, contrast agents, brachytherapy seeds). We constructed a side-firing fiber prototype for transurethral photoacoustic imaging of prostates with a dual-array (linear and curvilinear) transrectal ultrasound probe. A method to calculate the surface area and, thereby, estimate the laser fluence at this fiber tip was derived, validated, applied to various design parameters, and used as an input to three-dimensional Monte Carlo simulations. Brachytherapy seeds implanted in phantom, ex vivo, and in vivo canine prostates at radial distances of 5 to 30 mm from the urethra were imaged with the fiber prototype transmitting 1064 nm wavelength light with 2 to 8 mJ pulse energy. Prebeamformed images were displayed in real time at a rate of 3 to 5 frames per second to guide fiber placement and beamformed offline. A conventional delay-and-sum beamformer provided decreasing seed contrast (23 to 9 dB) with increasing urethra-to-target distance, while the short-lag spatial coherence beamformer provided improved and relatively constant seed contrast (28 to 32 dB) regardless of distance, thus improving multitarget visualization in single and combined curvilinear images acquired with the fiber rotating and the probe fixed. The proposed light delivery and beamforming methods promise to improve key prostate cancer detection and treatment strategies.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Muyinatu A. Lediju Bell, Xiaoyu Guo, Danny Y. Song, and Emad M. Boctor "Transurethral light delivery for prostate photoacoustic imaging," Journal of Biomedical Optics 20(3), 036002 (2 March 2015). https://doi.org/10.1117/1.JBO.20.3.036002

Published: 2 March 2015

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY