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15 December 2018 Characterization of healthy and nonmelanoma-induced mouse utilizing the Stokes–Mueller decomposition
Dan Linh Le, Trinh Ngoc Huynh, Dat Tan Nguyen, Toi Van Vo, Thi-Thu-Hien Pham
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Journal of Biomedical Optics, Vol. 23, Issue 12, 125003 (December 2018). https://doi.org/10.1117/1.JBO.23.12.125003
Abstract
Skin cancer is one of the most common cancers, including melanoma and nonmelanoma cancer. Melanoma can be easily detected by the observation of abnormal moles, but nonmelanoma signs and symptoms are not apparent in the early stages. We use the Stokes–Mueller matrix decomposition method to detect nonmelanoma at the early stage by decomposing the characteristics of polarized light interacting with normal and cancerous tissues. With this decomposition method, we extract nine optical parameters from biological tissues, namely the LB orientation angle (α), the LB phase retardance (β), the CB optical rotation angle (γ), the LD orientation angle (θd), the linear dichroism (D), the circular dichroism (R), the degrees of linear depolarization (e1 and e2), the degree of circular depolarization (e3), and the depolarization index (Δ). The healthy skin and the induced nonmelanoma skin cancer of mice are analyzed and compared based on their optical parameters. We find distinctive ranges of values for normal skin tissue and nonmelanoma skin cancer, in which β and D in cancerous tissue are larger and nonmelanoma skin becomes less depolarized. This research creates an innovative solid foundation for the diagnosis of skin cancer in the future.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Dan Linh Le, Trinh Ngoc Huynh, Dat Tan Nguyen, Toi Van Vo, and Thi-Thu-Hien Pham "Characterization of healthy and nonmelanoma-induced mouse utilizing the Stokes–Mueller decomposition," Journal of Biomedical Optics 23(12), 125003 (15 December 2018). https://doi.org/10.1117/1.JBO.23.12.125003
Received: 13 September 2018; Accepted: 27 November 2018; Published: 15 December 2018
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Cited by 14 scholarly publications.
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KEYWORDS
Skin cancer
Skin
Tissues
Dichroic materials
Tissue optics
Cancer
Polarization
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