Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging

Brian C. Wilson; Michael Jermyn; Frédéric Leblond

doi:10.1117/1.JBO.23.3.030901

6 March 2018 Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging

Brian C. Wilson, Michael Jermyn, Frédéric Leblond

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Journal of Biomedical Optics, Vol. 23, Issue 3, 030901 (March 2018). https://doi.org/10.1117/1.JBO.23.3.030901

Abstract

Medical devices face many hurdles before they enter routine clinical practice to address unmet clinical needs. This is also the case for biomedical optical spectroscopy and imaging systems that are used here to illustrate the opportunities and challenges involved. Following initial concept, stages in clinical translation include instrument development, preclinical testing, clinical prototyping, clinical trials, prototype-to-product conversion, regulatory approval, commercialization, and finally clinical adoption and dissemination, all in the face of potentially competing technologies. Optical technologies face additional challenges from their being extremely diverse, often targeting entirely different diseases and having orders-of-magnitude differences in resolution and tissue penetration. However, these technologies can potentially address a wide variety of unmet clinical needs since they provide rich intrinsic biochemical and structural information, have high sensitivity and specificity for disease detection and localization, and are practical, safe (minimally invasive, nonionizing), and relatively affordable.

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Brian C. Wilson, Michael Jermyn, and Frédéric Leblond "Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging," Journal of Biomedical Optics 23(3), 030901 (6 March 2018). https://doi.org/10.1117/1.JBO.23.3.030901

Received: 4 October 2017; Accepted: 25 January 2018; Published: 6 March 2018

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