Multiparameter interferometric polarization-enhanced imaging differentiates carcinoma in situ from inflammation of the bladder: an ex vivo study

Shuang Chang; Giovanna A. Giannico; Ezekiel Haugen; Ali Jardaneh; Justin Baba; Anita Mahadevan-Jansen; Sam S. Chang; Audrey K. Bowden

doi:10.1117/1.JBO.28.10.102907

10 August 2023 Multiparameter interferometric polarization-enhanced imaging differentiates carcinoma in situ from inflammation of the bladder: an ex vivo study

Shuang Chang, Giovanna A. Giannico, Ezekiel Haugen, Ali Jardaneh, Justin Baba, Anita Mahadevan-Jansen, Sam S. Chang, Audrey K. Bowden

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Journal of Biomedical Optics, Vol. 28, Issue 10, 102907 (August 2023). https://doi.org/10.1117/1.JBO.28.10.102907

Abstract

Significance

Successful differentiation of carcinoma in situ (CIS) from inflammation in the bladder is key to preventing unnecessary biopsies and enabling accurate therapeutic decisions. Current standard-of-care diagnostic imaging techniques lack the specificity needed to differentiate these states, leading to false positives.

Aim

We introduce multiparameter interferometric polarization-enhanced (MultiPIPE) imaging as a promising technology to improve the specificity of detection for better biopsy guidance and clinical outcomes.

Approach

In this ex vivo study, we extract tissue attenuation-coefficient-based and birefringence-based parameters from MultiPIPE imaging data, collected with a bench-top system, to develop a classifier for the differentiation of benign and CIS tissues. We also analyze morphological features from second harmonic generation imaging and histology slides and perform imaging-to-morphology correlation analysis.

Results

MultiPIPE enhances specificity to differentiate CIS from benign tissues by nearly 20% and reduces the false-positive rate by more than four-fold over clinical standards. We also show that the MultiPIPE measurements correlate well with changes in morphological features in histological assessments.

Conclusions

The results of our study show the promise of MultiPIPE imaging to be used for better differentiation of bladder inflammation from flat tumors, leading to a fewer number of unnecessary procedures and shorter operating room (OR) time.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Shuang Chang, Giovanna A. Giannico, Ezekiel Haugen, Ali Jardaneh, Justin Baba, Anita Mahadevan-Jansen, Sam S. Chang, and Audrey K. Bowden "Multiparameter interferometric polarization-enhanced imaging differentiates carcinoma in situ from inflammation of the bladder: an ex vivo study," Journal of Biomedical Optics 28(10), 102907 (10 August 2023). https://doi.org/10.1117/1.JBO.28.10.102907

Received: 4 May 2023; Accepted: 31 July 2023; Published: 10 August 2023

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KEYWORDS

Tissues

Inflammation

Biological samples

Collagen

Second harmonic generation

Tumors

Birefringence

Significance

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